2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-28247
    N-Formylkynurenine 1022-31-7 98%
    N-Formylkynurenine is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine. The formation of N-formylkynurenine is catalyzed by heme dioxygenases.
    N-Formylkynurenine
  • HY-32338
    Tacalcitol monohydrate 93129-94-3 99.85%
    Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.
    Tacalcitol monohydrate
  • HY-34781
    4'-Trifluoromethyl-2-biphenyl carboxylic acid 84392-17-6 ≥98.0%
    4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent.
    4'-Trifluoromethyl-2-biphenyl carboxylic acid
  • HY-48289
    PKA/AKAP-IN-2 304888-67-3 98%
    PKA/AKAP-IN-2 (15109) is a non-peptide inhibitor of the interaction between protein kinase A (PKA) and A kinase anchoring proteins (AKAP). PKA/AKAP-IN-2 can be utilized in research related to cAMP disturbance associated diseases.
    PKA/AKAP-IN-2
  • HY-69262
    2-(Hexadecyloxy)-1,3-propanediol 1931-78-8 98%
    2-(Hexadecyloxy)-1,3-propanediol (1,3-Propanediol,2-(hexadecyloxy)-) is an ester product.
    2-(Hexadecyloxy)-1,3-propanediol
  • HY-75279
    N-Acetyl-β-neuraminic acid methyl ester 22900-11-4 ≥98.0%
    N-Acetyl-β-neuraminic acid methyl ester (N-Acetyl-Neuraminic acid (Sialic acid)) is an ester product.
    N-Acetyl-β-neuraminic acid methyl ester
  • HY-76802
    Calcitriol Derivatives 2070009-24-2 99.55%
    Calcitriol Derivatives is a vitamin D3 analog.
    Calcitriol Derivatives
  • HY-A0185
    Calcium Gluceptate 29039-00-7 98%
    Calcium Gluceptate is a calcium supplement. Calcium Gluceptate can be used for hypocalcaemia research.
    Calcium Gluceptate
  • HY-B0700
    Rosiglitazone sodium 316371-83-2 98%
    Rosiglitazone sodium is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone sodium is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
    Rosiglitazone sodium
  • HY-B1045
    Chlorazanil hydrochloride 2019-25-2 98%
    Chlorazanil hydrochloride is an orally effective diuretic.
    Chlorazanil hydrochloride
  • HY-B1351
    Bilberry Extract 84082-34-8 98%
    Bilberry Extract is a bilberry extract, and its components include: Anthocyanidins. Bilberry Extract has potential antioxidant activity and can regulate specific metabolic enzymes in the liver, such as cytochrome P450 (CYP) 2C11 and CYP2E1 involved in drug metabolism..
    Bilberry Extract
  • HY-B2030
    Propanil 709-98-8
    Propanil is a widely used contact herbicide, primarily for rice.
    Propanil
  • HY-B2097
    Incadronate disodium 138330-18-4 98%
    Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research.
    Incadronate disodium
  • HY-D2261
    BODIPY-cholesterol conjugate-1 1638745-25-1 98%
    BODIPY-cholesterol conjugate-1 (compound 5) is a BODIPY-cholesterol conjugate. BODIPY-cholesterol conjugate-1 is a useful probe for simultaneous visualization of intracellular cholesterol pools and for monitoring cholesterol efflux from cells to extracellular acceptors. (λex 541 nm, λem 615 nm).
    BODIPY-cholesterol conjugate-1
  • HY-D2262
    BODIPY-cholesterol conjugate-2 1638745-26-2 98%
    BODIPY-cholesterol conjugate-2 (compound 6) is a BODIPY-cholesterol conjugate. BODIPY-cholesterol conjugate-2 is a useful probe for simultaneous visualization of intracellular cholesterol pools and for monitoring cholesterol efflux from cells to extracellular acceptors. (λex=589 nm, λem=638 nm).
    BODIPY-cholesterol conjugate-2
  • HY-D2357
    Lactat-CY5 98%
    Lactat-CY5 is Cy5-labeled Lactat (HY-B2227). Lactat-CY5 can be used to localize Lactat in living cells.
    Lactat-CY5
  • HY-D2358
    Glucosamine-CY5.5 98%
    Glucosamine-CY5.5 is CY5.5-labeled Glucosamine (HY-B1125). Glucosamine-CY5.5 can be used to localize Glucosamine in living cells.
    Glucosamine-CY5.5
  • HY-D2359
    Glucosamine-FITC 98%
    Glucosamine-FITC is FITC-labeled Glucosamine (HY-B1125). Glucosamine-FITC can be used to localize Glucosamine in living cells.
    Glucosamine-FITC
  • HY-D2414
    SCOTfluor-89 2490298-72-9 98%
    SCOTfluor-89 is a small, conjugatable, orthogonal and multi-colored fluorophores for in vivo imaging of cell metabolism.
    SCOTfluor-89
  • HY-D2480
    BODIPY 480/508-cholesteryl linoleate 2260795-60-4 98%
    BODIPY 480/508-cholesteryl linoleate is a cell-permeable and fluorescently tagged derivative of Cholesteryl Linoleate (HY-W010697). BODIPY 480/508-cholesteryl linoleate has been used to monitor cholesterol trafficking in isolated human monocyte-derived macrophages (Ex/Em=480/508 nm).
    BODIPY 480/508-cholesteryl linoleate
Cat. No. Product Name / Synonyms Application Reactivity